Scott A Waldman Selected Research

Guanylate Cyclase (Guanylyl Cyclase)

10/2021	The shifting paradigm of colorectal cancer treatment: a look into emerging cancer stem cell-directed therapeutics to lead the charge toward complete remission.
1/2021	Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential.
1/2018	Modeling qRT-PCR dynamics with application to cancer biomarker quantification.
1/2018	The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia.
1/2018	Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders.
6/2017	Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention.
5/2017	Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.
12/2016	Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope.
10/2016	Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.
2/2009	Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer.

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Scott A Waldman Research Topics

Disease

84	Neoplasms (Cancer) 06/2022 - 03/2002
70	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 08/2002
26	Carcinogenesis 01/2022 - 08/2007
19	Colonic Neoplasms (Colon Cancer) 01/2022 - 03/2002
18	Neoplasm Metastasis (Metastasis) 01/2019 - 08/2002
11	Obesity 01/2021 - 06/2010
5	Diarrhea 01/2018 - 12/2006
5	Adenocarcinoma 04/2006 - 03/2002
4	Constipation 01/2022 - 01/2010
4	Inflammation (Inflammations) 10/2018 - 12/2014
4	Metaplasia 08/2009 - 07/2003
3	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2021 - 01/2019
3	Disease Progression 01/2021 - 03/2006
3	Carcinoma (Carcinomatosis) 01/2020 - 09/2005
3	Adenoma (Adenomas) 01/2020 - 01/2010
3	Infections 01/2020 - 08/2007
3	Insulin Resistance 10/2018 - 03/2013
3	Lymphatic Metastasis 01/2010 - 02/2009
3	Vomiting 01/2008 - 05/2003
3	Nausea 01/2008 - 05/2003
3	Neoplasm Micrometastasis 08/2006 - 07/2003
2	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2022 - 01/2010
2	Hypersensitivity (Allergy) 01/2022 - 05/2003
2	Weight Loss (Weight Reduction) 01/2021 - 06/2013
2	Heart Failure 12/2020 - 03/2017
2	Hyperphagia (Overeating) 01/2019 - 09/2016
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2018 - 11/2013
2	Uremia 08/2016 - 12/2014
2	Chronic Kidney Failure (Chronic Renal Failure) 12/2014 - 03/2013
2	Atherosclerosis 12/2014 - 01/2004
2	Asthma (Bronchial Asthma) 12/2014 - 01/2004
2	Melanoma (Melanoma, Malignant) 07/2014 - 04/2011
2	Breast Neoplasms (Breast Cancer) 07/2014 - 04/2014
1	Abdominal Pain (Pain, Abdominal) 01/2022
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2021

Drug/Important Bio-Agent (IBA)

49	Enterotoxin ReceptorsIBA 01/2022 - 03/2002
25	Hormones (Hormone)IBA 12/2021 - 08/2008
20	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2002
19	LigandsIBA 01/2022 - 03/2002
16	AntigensIBA 06/2022 - 06/2007
14	guanylinIBA 01/2022 - 08/2007
13	VaccinesIBA 06/2022 - 07/2008
12	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2005
11	uroguanylinIBA 01/2022 - 08/2007
10	Guanylate Cyclase (Guanylyl Cyclase)IBA 10/2021 - 02/2009
10	Enterotoxins (Enterotoxin)IBA 01/2018 - 09/2005
9	Messenger RNA (mRNA)IBA 10/2020 - 08/2002
8	linaclotideIBA 01/2021 - 01/2016
8	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 11/2014 - 07/2003
5	Pharmaceutical PreparationsIBA 01/2022 - 05/2003
5	AutoantigensIBA 01/2020 - 04/2009
5	CarcinogensIBA 12/2017 - 08/2007
4	Cancer VaccinesIBA 01/2022 - 05/2013
4	plecanatideIBA 01/2021 - 01/2017
4	CytokinesIBA 10/2018 - 04/2008
3	EpitopesIBA 01/2022 - 05/2012
3	Guanylate Cyclase-Coupled ReceptorsIBA 01/2021 - 12/2006
3	Chimeric Antigen ReceptorsIBA 10/2020 - 12/2011
3	AdiponectinIBA 08/2016 - 03/2013
3	MicroRNAs (MicroRNA)IBA 06/2009 - 05/2007
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2008 - 05/2003
3	Aprepitant (Emend)FDA Link 01/2008 - 05/2003
2	RNA (Ribonucleic Acid)IBA 01/2022 - 08/2006
2	Guanylyl Cyclase C AgonistsIBA 01/2022 - 09/2005
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2017
2	CateninsIBA 01/2022 - 01/2020
2	dolcanatideIBA 12/2021 - 01/2018
2	Sildenafil Citrate (Viagra)FDA Link 01/2021 - 10/2020
2	Glucose (Dextrose)FDA LinkGeneric 10/2018 - 08/2016
2	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 10/2016 - 05/2006
2	Peptides (Polypeptides)IBA 10/2016 - 04/2007
2	Cyclic GMPIBA 10/2016 - 04/2009
2	Methacholine Chloride (Methacholine)FDA Link 02/2015 - 12/2014
2	Dexamethasone (Maxidex)FDA LinkGeneric 06/2013 - 01/2008
2	CDX2 Transcription FactorIBA 08/2010 - 12/2005
2	NF-kappa B (NF-kB)IBA 08/2009 - 04/2006
2	Bile Acids and Salts (Bile Acids)IBA 08/2009 - 04/2006
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 04/2009 - 03/2006
2	Interleukin-2 (IL2)IBA 12/2008 - 04/2008
2	AzoxymethaneIBA 09/2008 - 08/2007
2	Serotonin (5 Hydroxytryptamine)IBA 01/2008 - 05/2003
2	GuanosineIBA 05/2006 - 12/2005
1	LeptinIBA 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Immunoconjugates (Immunoconjugate)IBA 10/2020
1	Neutralizing AntibodiesIBA 01/2020
1	prouroguanylinIBA 01/2019

Therapy/Procedure

40	Therapeutics 01/2022 - 05/2003
17	Immunotherapy 06/2022 - 06/2007
15	Drug Therapy (Chemotherapy) 01/2021 - 05/2003
7	Chemoprevention 01/2021 - 04/2009
5	Hormone Replacement Therapy (Therapy, Hormone Replacement) 09/2016 - 04/2009
4	Adjuvant Chemotherapy 12/2016 - 11/2009
2	Lasers (Laser) 01/2021 - 03/2006
2	Precision Medicine 01/2021 - 12/2009
2	Cell- and Tissue-Based Therapy (Cell Therapy) 03/2017 - 05/2013
2	Radiotherapy 04/2014 - 02/2013
1	Injections 12/2020
1	Intramuscular Injections 01/2019